7 Best Ergonomic Mouse in 2023

Reviewed by Betsy Sanchez
Betsy Sanchez

Betsy Sanchez is a professional graphic designer with over 10 years of experience. She loves all things tech and that's why she started writing on different topics online now here, working with us to help the audience who are looking for perfect comfort.

Best Ergonomic Mouse

Thousands of mice with tags like “best ergonomic mouse” are available on various marketplaces.

However, most of these mice will disappoint you when you use the product. It could be due to their poor design, fragile built quality, or lack of features. 

We picked a few mice a few weeks back, and after a few days of testing, we were left with only a handful of options. 

Out of these handfuls of options, we have created a list of the 7 Best Ergonomic Mouse. All the below-listed mice are worth their price and offer best-in-class comfort.

Now, let’s begin with the list:

1. Logitech MX Master 3

  • Connectivity: Wireless
  • Compatible Devices: Mac & Windows
  • Color: Graphite, Mid Grey

More features: Electromagnetic Scroll Wheel, Connectivity with multiple devices simultaneously.

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Logitech MX Master 3

If you are looking for a best-in-class mouse that would work flawlessly, Logitech MX Master 3 is the best mouse you can buy right now.

This mouse is best suited for medium-sized and large palms. You get a dedicated button at the thumb rest (on the top of the mouse) to enable gesture controls. The scroll wheel uses the electromagnetic mechanism, and it automatically enables the free-scroll technology while scrolling through a long document.

Logitech Mx Master 3 works on almost all desk surfaces thanks to the top-notch laser sensor.

The mouse ensures that your wrist and forearm muscles are well-rested and maintain a natural position. While using the mouse, we found that Mx Master 3 offers buttery smooth movement and comes with minimal latency.

If you need an ergonomic mouse that is portable and easy to carry, MX Master 3 might not be the appropriate option for you as it looks bulky and won’t fit in small laptop backpacks. Also, you don’t get a dedicated USB receiver storage slot in the mouse, which adds up an additional task to keep the receiver handy while traveling.

You can connect the mouse with up to three devices simultaneously. Also, you get a USB C port to charge the internal battery. With a single charge, the mouse can last up to 80 days, and with a charge of 1 minute, it can last for 3 hours.

The vertical scroll wheel and two side buttons are perfect companions for video editors and graphic designers. You can also customize the buttons using Logitech customization software.

Overall it’s a perfect ergonomic mouse for a desk loaded with many useful features.


  • Electromagnetic Scroll Wheels
  • Built Quality
  • USB C Charging
  • Cross Computer Control up to three devices
  • Rechargeable Battery Powered
  • Smooth Cursor movement


  • Looks Bulky
  • It doesn’t have a built-in USB receiver storage slot

2. Anker 2.4G Wireless Vertical Ergonomic Optical Mouse

  • Connectivity: USB Wireless Receiver
  • Compatible Devices: Mac & Windows
  • Color: Black

More features: Vertical mouse, Power saving mode.

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Anker 2 4G Wireless Vertical Ergonomic Optical Mouse

If you are a vertical mouse person, you must check the Anker 2.4G wireless ergonomic vertical mouse.

Studies show that vertical mice are better than traditional mice. However, some people get extremely uncomfortable with the vertical mouse buttons’ layout and design.

We would say you must give the vertical mouse a try, and if it works well, you can switch over it permanently.

Anker 2.4G wireless mouse is an elegant vertical mouse with industry-standard built quality. It has the perfect ergonomic design.

It keeps your wrist and arm in a natural position or, as the manufacturer says, in the handshake position.

This vertical mouse comes with three (800/1200/1600) DPI resolution options, and it works on the optical tracking technology that ensures smooth mouse movements on the majority of the desk surfaces.

While internet surfing, the two additional buttons placed on the side of the mouse come in handy to navigate back and forward.

The product’s dimensions are planned so smartly that it can offer comfort to all palm sizes. This mouse is powered with two aaa batteries. You also get an 18-month warranty on it. Anker 2.4G wireless ergonomic mouse is one of the best vertical mice you can get in 2023.


  • Ergonomic Vertical Design
  • Additional two buttons
  • Three DPI resolution options


  • No Electromagnetic or Free Scroll Wheel
  • No Rechargeable Battery

3. R-Go Tools USB Wired Vertical Ergonomic Break Mouse

  • Connectivity: Wired
  • Compatible Devices: Mac & Windows
  • Color: Black, Silver

More features: Plug and Play, Smart Break Mode.

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R Go Tools USB Wired Vertical Ergonomic Break Mouse

Here we are with another vertical mouse. This time, we have a bit of special vertical mice with us.

R-GO USB wired vertical ergonomic mouse will work as a pointer device and as a reminder tool.

This mouse ensures that you are taking regular breaks throughout the day. The idea is quite exciting and realistic.

You get a LED indicator on the left side of the mouse; it has three different colors. Green Indicates that you are taking regular breaks, Yellow indicates that you should take a break immediately, and the Red indicates that you have skipped a break and your arm and wrist muscles are under pressure.

This mouse also comes with a built-in technology that studies your mouse usage and, based on that, it plots graphs and makes suggestions accordingly.

For instance, if you are using your mouse intensively, you will be suggested a few quick keyboard shortcuts to reduce your mouse usage.

The break timings are:

  • 30 Seconds break after every 10 minutes of work
  • 5 Minutes break after an hour of work

R-GO vertical mice are well built and follow all the ergonomic norms. It ensures that you don’t suffer from wrist pain.

Also, it stimulates the mouse movement to engage your arms instead of your wrist.

Using the R-GO Break software, you can customize buttons and increase productivity.

Apart from this, you can get the most appropriate mouse as per your palm size. Yes! You get multiple options for a single product.


  • Multiple Product Sizes
  • Break Indicator
  • Ergonomic Design
  • Customizable Buttons


  • Wired
  • No Vertical Scroll Wheel

4. Logitech MX Vertical Wireless Mouse

  • Connectivity: Bluetooth, USB receiver
  • Compatible Devices: Mac & Windows
  • Color: Graphite

More features: Ergonomic Vertical Design, Rechargeable Battery, Up to three device connectivity.

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Logitech MX Vertical Wireless Mouse

Logitech MX Vertical mouse is one of the top-rated ergonomic mice that you can get for under $100.

The vertical design reduces most of the wrist strain. Using this mouse, you can avoid compression on your hand muscles. It is most suitable for people who spend more than 7-8 hours at the desk.

The advance and high-precision laser sensor ensures smooth mouse movement on a wide range of desk surfaces.

This mouse comes with a 4000 DPI resolution which offers 4x less wrist movement than a traditional mouse.

In terms of build quality, Logitech MX vertical feels rock solid.

It has an internal battery that offers four months of continuous battery life on a single charge, and with the quick charging Type C port, you can get 3 hours of battery life in just 1 minute of charge.

It’s a great desk mouse like the Logitech MX master 3; however, if you are looking for a portable option, we are afraid the Logitech MX Vertical is also not the most suitable option for you. It’s bulky.

Like most of the mice from the MX series, this also comes with multi-device connectivity.

Also, you must note that, unlike Mx Master 3, this mouse doesn’t automatically enable the free-scrolling while going through long web pages, which was not a deal-breaker for us.

The Bluetooth connectivity adds up as an additional feature on this mouse over other Logitech MX mice.

Overall, Logitech MX vertical mouse is among the best ergonomic wireless mouse.


  • Ergonomic Vertical Design
  • High Precision 4000 DPI resolution sensor
  • Type C charging with quick charge technology
  • 4 Months of Battery Life
  • Multi-Device Connectivity


  • Bulky
  • No Vertical Scroll wheel

5. J-Tech Digital Wired Ergonomic Vertical USB Mouse

  • Connectivity: Wired
  • Compatible Devices: Mac & Windows
  • Color: Black

More features: Adjustable DPI Sensitivity, LED Light, Anti-Skid, and Anti-Sweat removable Palm rest.

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J Tech Digital Wired Ergonomic Vertical USB Mouse

If you are looking for a cheap and reliable vertical mouse, this J-tech digital wired mouse is the best option.

It is an excellent mouse for under $50; unlike other ergonomic mice under $40-$50, it is well built and offers thumb rest with two back/forward buttons.

On this mouse, you can adjust the DPI resolution as per your requirement and reduce the chances of repetitive stress injuries.

You get a blue led light strip covering the top and bottom of the mouse, so it could be your perfect option if you are looking for a cheap and reliable vertical gaming mouse.

Though it is not a dedicated gaming mouse, but it has a removal anti-skid and anti-sweat palm rest. Thi palm rest enhances the overall gaming experience.

Under $50, it is one of the few mice that offers brilliant ergonomic benefits to both mac and windows users.

Using this mouse with its anti-skid palm rest reduces maximum strain from your carpal tunnel and wrist.

With this device, you get a one-year limited warranty and a lifetime of free technical support.

Depending on your palm dimensions, you can select the most appropriate mouse out of two different mice sizes.

Overall it adds up to a decent budget ergonomic gaming mice.


  • Anti-Skid and Anti Sweat Removable Palm Rest
  • Fairly Priced
  • Multiple Products Sizes
  • Lifetime Technical Support


  • Wired Connectivity

6. Razer Basilisk V3

  • Connectivity: Wired
  • Compatible Devices: Mac & Windows
  • Color: Classic Black

More features: 26000 DPI Optical Sensor, 11 Programmable Buttons, HyperScroll Tilt Wheel.

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Razer Basilisk V3

If you want a gaming mouse with a horizontal orientation, the Razer basilisk v3 is the ultimate option.

Razer Basilisk V3 is one of the best ergonomic gaming mice. It comes with 11 reprogrammable keys and a Hyper Scroll tilt wheel.

The HyperScroll tilt wheel works in free scroll mode by default, but you can switch to the tactile mode for better precision.

Razer Basilisk V3 mouse has a best-in-class optical sensor with 26K DPI resolution; this high sensitivity optical sensor offers pixel-precise accuracy.

Its iconic ergonomic design with dedicated thumb rest ensures that your wrist doesn’t undergo any additional strain and your hands stay in their natural position.

The RGB Backlit, with more than 16 million color combinations, the mouse will add up to the aesthetics of the desk.

Apart from all these, the mouse has five onboard memory profiles. Therefore, you won’t have to program the same keys multiple times.

Overall, it is one of the best budget ergonomic mice for under $80.


  • RGB Backlit Mouse
  • HyperScroll Tilt Wheel
  • 26K DPI Resolution
  • Dedicated Thumb Rest
  • 2 Years of Warranty


  • No Wireless Option

7. Evoluent VM4R VerticalMouse 4 Right Hand Ergonomic Mouse

  • Connectivity: Wired
  • Compatible Devices: Mac & Windows
  • Color: Grey

More features: Customisable Buttons, Adjustable Mouse Speed.

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Evoluent VM4R Vertical Mouse

Evoluent VM4R Vertical Mouse is a solid built with big footprints. These attributes make it a perfect option for larger palm people.

It has six buttons, out of which two are reprogrammable. You can download the Freeware Customization software to program the keys as per your requirements.

Using the customizable DPI resolution, you can adjust the mouse pointer speed. Besides this, the mouse offers a decent hand grip.

The thumb rest ensures that your thumb resting comfortably on it, and both the buttons are easy-to-reach.

This mouse has a wide lip that provides additional fingertip grip and better hovering on various desk surfaces. Everything will be comfortably resting on the mouse, from the thumb to the index finger.

The Scroll wheel is packed with the Hyper Scrolling technology that allows sensitive and free-scrolling on long web pages.

The ergonomic mouse design ensures that your wrist and hands are always in their natural position and have minimum strain. This is a great mouse in the best ergonomic mice category.


  • Provides natural position for the hand and wrist
  • Customizable Buttons
  • Zero-latency
  • Hyper Scrolling
  • 11 Programmable Buttons


  • No Bluetooth Connectivity
  • Only suitable for large palm sizes


We hope you have a clear picture of the perfect mouse for you.

Although we have listed a wide spectrum of mice, quantitatively, these might seem less.

So, we would like to inform you that buyers rarely have any complaints after buying the products mentioned above, and these mice will last for years. All the above-mentioned mice are the most reliable and ergonomic options.

Do let us know if you have any queries. Share it with your friends if you find this content helpful.